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The cultivation of synthetic skin has the potential to effectively halt the progression of skin cancer, as per findings from the University of Copenhagen. This innovative skin model may facilitate the comprehension of how cancer adversely affects skin structures and subverts the functionality of normal cells for medical professionals.

Disruptions in TGF beta pathway in cell signalling leads to cancer

In a normal, healthy body, skin damage triggers the production of new skin layers without invading the hypodermis. In contrast, in the presence of cancer, skin cells lose their confinement and begin infiltrating multiple skin layers, potentially resulting in invasive growth.

Preventing the invasive expansion of skin cancer could mitigate its proliferation, and the researchers in this investigation posit that accomplishing this objective is attainable by targeting the TGF-beta pathway.

Research has focused on the TGF beta pathway in cell signaling, a vital mechanism regulating cell growth and division. Hans Wandall, a professor at the University of Copenhagen, highlights its significance and warns that disruptions in this pathway can lead to cancerous transformation and tissue invasion.

Several drugs exist for the inhibition of the TGF signaling pathway, and the subsequent phase involves assessing its efficacy in a model of skin cancer. This novel artificial skin plays a crucial role in this context.

Synthetic skin uses genetically modified skin cells

Researchers have developed an artificial skin that closely resembles and functions like real human skin. This synthetic skin utilizes genetically modified human skin cells derived from subcutaneous tissue, mimicking the layered growth of natural skin. Furthermore, this model enables rapid genetic alterations, facilitating the study of various skin disorders beyond just skin cancer.

Using artificial human skin eliminates concerns about the transferability of results from mouse tests to humans. This marks a shift from using mice models in most studies of this nature, allowing for more reliable conclusions about the safety and efficacy of substances, as artificial skin brings us closer to human reality.

The artificial skin, allows researchers to study molecule interactions and skin damage at the organ level, but it doesn’t enable testing the effect of drugs on the body.