Understanding TNBC – A Comprehensive Guide for Seniors

What is Triple-Negative Breast Cancer?

Breast cancer is a diverse disease with several subtypes, each requiring tailored treatment approaches. Triple-Negative Breast Cancer (TNBC) is a less common but more aggressive form, accounting for approximately 10-20% of all breast cancer cases. TNBC occurs when the cancerous cells lack receptors for estrogen, progesterone, and human epidermal growth factor receptor 2 (HER2), making it challenging to treat with targeted therapies.

Symptoms and Risk Factors

TNBC often presents as a palpable lump or thickening in the breast, with or without breast pain or nipple discharge. However, many cases are initially asymptomatic, underscoring the importance of regular breast screenings and self-examinations, especially for women over 50.

While the exact causes of TNBC are not fully understood, certain factors may increase the risk, including genetic mutations (such as BRCA1 and BRCA2), younger age at diagnosis, and African or Hispanic ancestry.

Treatment Options for TNBC

Due to the lack of targeted therapies, TNBC is typically treated with a combination of conventional methods, including:

Surgery: Depending on the stage and extent of the cancer, surgery may involve lumpectomy (removal of the tumor) or mastectomy (removal of the entire breast).

Chemotherapy: TNBC often responds well to chemotherapy, which can be administered before or after surgery to shrink the tumor or eliminate any remaining cancer cells.

Radiation Therapy: Radiation may be used in conjunction with surgery and chemotherapy to target and destroy any remaining cancer cells in the affected area.

Innovative Therapies

Researchers are continuously exploring new treatment avenues for TNBC, including targeted therapies and immunotherapies. One promising development is the FDA-approved drug Trodelvy (sacituzumab govitecan-hziy), which targets a protein called Trop-2, commonly found on TNBC cells. This antibody-drug conjugate has shown promising results in clinical trials, offering hope for patients with advanced or metastatic TNBC.

Support and Survivorship

Battling TNBC can be physically and emotionally challenging, especially for seniors. Building a strong support network, including healthcare professionals, counselors, and support groups, can be invaluable during this journey. Additionally, maintaining a healthy lifestyle, managing treatment side effects, and exploring complementary therapies can contribute to overall well-being and improved quality of life.

TNBC may be an aggressive form of breast cancer, but with early detection, personalized treatment plans, and ongoing research, many seniors are achieving long-term remission and survivorship. Staying informed, advocating for your health, and maintaining a positive outlook can make a significant difference in your TNBC journey.

This information does not constitute medical advice and it should not be relied upon as such.
Consult with your doctor before modifying your regular medical regime.