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A recent study suggests that specific genes associated with an increased risk of Alzheimer’s disease may also raise the likelihood of developing epilepsy. Furthermore, individuals with a particular type of epilepsy may have a higher chance of developing Alzheimer’s.

Alzheimer’s disease patients at risk of epilepsy

According to a study by Jiali Pu, PhD, from Zhejiang University School of Medicine, individuals with Alzheimer’s disease have a higher risk of developing epilepsy. Furthermore, the study reveals that those with focal epilepsy, which constitutes over 50% of all epilepsy cases, are also more susceptible to developing Alzheimer’s disease.

In their study, Chinese researchers conducted a genome-wide association study on 111,326 individuals with Alzheimer’s disease and 677,663 individuals without the condition. They examined genetic variations by analyzing long DNA strands to identify differences between the two groups. To determine the potential causal relationship between genetic variations and the risk of epilepsy, they employed Mendelian randomization in their study design.

Findings indicate that individuals with Alzheimer’s disease have a 5.3% higher chance of developing generalized epilepsy, a condition characterized by seizures originating from both sides of the brain. Furthermore, they also face a 1.3% increased risk of focal epilepsy with hippocampal sclerosis, which involves recurring seizures limited to one side of the brain.

Individuals with Alzheimer’s disease have been found to have a 5.3% higher chance of developing generalized epilepsy, a condition characterized by seizures originating from both sides of the brain. Furthermore, they also face a 1.3% increased focal epilepsy risk with hippocampal sclerosis, a condition characterized by recurring seizures on one side of the brain.

Focal epilepsy individuals are more likely to develop Alzheimer’s

In a study, researchers examined the genetic differences between 15,212 individuals with epilepsy and 29,677 individuals without epilepsy. They found that focal epilepsy individuals having hippocampal sclerosis had a significantly higher risk of developing Alzheimer’s disease, almost four times more than those without epilepsy. Researchers evaluated genetic differences of individuals and found that individuals with high levels of the amyloid biomarker were at increased risk of generalized anxiety than those with low levels.